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KMID : 0364920060310020091
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Journal of Radiation Protection and Research
2006 Volume.31 No. 2 p.91 ~ p.96
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The Effects of MRI on Mouse Embryos During Fetal Stage
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Nakamura Takashi
Ryu Myung-Sunz
Sakazaki Takahiko
Itokawa Yuk
Maenaka Toshihiro
Masubuchi Takashi
Sekimoto Hiroyuki
Kanehara Masayuki
Kang Young-Nam
Gu Yeon-Hwa
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Abstract
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The effects of Magnetic resonance imaging (MRI) on mouse embryos at the early stage of organogenesis were investigated. Pregnant ICR mice were exposed on day 8 of gestation to MRI at 0.5 T for 0.5 hour to 3 hours. The mortality rates of embryos or fetuses, the incidence of external malformations, fetal body weight and sex ratio were observed at day 18 of gestation. A significant increase in embryonic mortality was observed after exposure to either 0.5 T MRI for 0.5 hour or 2 hours. However, the exposure to MRI for 1 hour or 3 hours did not induce any significant increase in embryonic mortality when compared with control. External malformations such as exencephaly, cleft palate and anomalies of tail were observed in all experimental groups exposed to each MRI. A statistically significant increase of external malformations was observed in all groups treated with 0.5 T MRI for 0.5 hour and 3 hours. The incidence of external malformations in the mice group exposed to 0.5 T MRI for 0.5-hour was found to be higher than those of mice group exposed to 0.5 T MRI for 2 hours. The effects of MRI on the external malformations might not to be dose-dependent. There was no statistically significant difference in fetal body weight and sex ratio among each MRI exposure groups.
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KEYWORD
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Embryonic effects, Organogenesis, Malformation, Magnetic Resonance Imaging(MRI)
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